Retinopathy of Prematurity. Current Concepts and Controversies

Current Concepts of Oxygen Management in Retinopathy of Prematurity

Retinopathy of prematurity (ROP) is a potentially blinding disorder in premature infants. The underlying pathophysiology is incompletely understood, limiting the prevention and treatment of this devastating condition. Current therapies are directed toward management of aberrant neovascularization thought to result from retinal ischemia in the developing preterm retina. The molecular mediators i...

Current Concepts and Controversies in Orthopaedic Oncology

The manuscripts in this thematic issue on musculoskeletal oncology present different techniques and address difficult topics that have received limited attention in the current literature. Because of the wide variety of clinical situations encountered with bone and soft tissue tumors, it is essential for oncologic surgeons to be both facile and versatile. The following manuscripts contain valua...

Shoulder Instability. Current Concepts and Controversies

Early onset scoliosis: current concepts and controversies.

Early Onset Scoliosis (EOS) may be associated with long-term pulmonary morbidity, which is not commonly seen in Adolescent Idiopathic Scoliosis. Initial evaluation is based on determining any underlying etiology related to congenital or syndromic conditions. Assessing the impact of scoliosis on thoracic development may help guide treatment, which is often required at a young age in these childr...

Multifocal motor neuropathy: current concepts and controversies.

Multifocal motor neuropathy (MMN) is now a well-defined purely motor multineuropathy characterized by the presence of multifocal partial motor conduction blocks (CB), frequent association with anti-GM1 IgM antibodies, and usually a good response to high-dose intravenous immunoglobulin (IVIg) therapy. However, several issues remain to be clarified in the diagnosis, pathogenesis, and therapy of t...